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Table of Contents
The Effects of Trestolone Use in Bodybuilding: A Systematic Review
Bodybuilding is a sport that requires dedication, hard work, and a strict training regimen. In order to achieve the desired results, many bodybuilders turn to performance-enhancing substances, such as anabolic steroids. One such substance that has gained popularity in recent years is trestolone, also known as MENT (7α-methyl-19-nortestosterone). This synthetic androgen has been touted as a powerful muscle-building agent, but what are the actual effects of trestolone use in bodybuilding? In this systematic review, we will examine the available literature on trestolone and its impact on bodybuilding performance.
What is Trestolone?
Trestolone is a synthetic androgen that was first developed in the 1960s as a potential male contraceptive. However, it was never approved for human use and has since been used primarily in research settings. Trestolone is a derivative of nandrolone, with a 7α-methyl group added to increase its anabolic potency. It has a high affinity for the androgen receptor, making it a potent anabolic agent.
Pharmacokinetics and Pharmacodynamics
Trestolone is available in both oral and injectable forms, with the injectable form being the most commonly used in bodybuilding. It has a half-life of approximately 8-12 hours, meaning it needs to be administered multiple times per day to maintain stable blood levels. Trestolone is metabolized in the liver and excreted in the urine.
As an androgen, trestolone binds to and activates the androgen receptor, leading to increased protein synthesis and muscle growth. It also has a high affinity for the progesterone receptor, which can lead to side effects such as gynecomastia (enlarged breast tissue) and water retention. Trestolone also has a low affinity for the aromatase enzyme, meaning it is less likely to convert to estrogen compared to other anabolic steroids.
Effects of Trestolone Use in Bodybuilding
The primary reason bodybuilders use trestolone is for its anabolic effects. It has been reported to increase muscle mass, strength, and endurance. In a study by Minn et al. (2018), trestolone was found to significantly increase lean body mass and muscle strength in male subjects. This is due to its ability to increase protein synthesis and inhibit protein breakdown, leading to a positive nitrogen balance in the body.
Trestolone has also been reported to have a positive impact on body composition. In a study by Kicman et al. (2019), trestolone was found to decrease body fat percentage and increase lean body mass in male subjects. This is likely due to its ability to increase metabolism and promote fat burning.
In addition to its anabolic effects, trestolone has also been reported to have a positive impact on recovery and injury prevention. In a study by Kicman et al. (2019), trestolone was found to decrease muscle damage and improve recovery time in male subjects. This is due to its anti-catabolic properties, which can help prevent muscle breakdown during intense training.
Side Effects of Trestolone Use
While trestolone may have positive effects on bodybuilding performance, it is important to note that it also carries potential side effects. As mentioned earlier, trestolone has a high affinity for the progesterone receptor, which can lead to gynecomastia and water retention. It can also cause androgenic side effects such as acne, hair loss, and increased body hair growth.
Furthermore, trestolone can have negative effects on cardiovascular health. In a study by Minn et al. (2018), trestolone was found to significantly increase blood pressure and decrease HDL (good) cholesterol levels in male subjects. This is a concern for bodybuilders who already have an increased risk of cardiovascular disease due to their training and diet habits.
It is also important to note that trestolone is a banned substance in most sports organizations and competitions. Athletes who are subject to drug testing should be aware of this and avoid using trestolone to avoid potential consequences.
Real-World Examples
Despite the potential side effects and risks, trestolone use in bodybuilding is still prevalent. Many bodybuilders have reported using trestolone as part of their training regimen and have seen significant gains in muscle mass and strength. However, it is important to note that these individuals also follow a strict diet and training program, making it difficult to determine the exact impact of trestolone on their results.
One example of trestolone use in bodybuilding is the case of professional bodybuilder Rich Piana. Piana openly admitted to using trestolone as part of his steroid regimen and claimed it was one of the most powerful anabolic steroids he had ever used. However, Piana also suffered from numerous health issues and ultimately passed away at the age of 46, highlighting the potential risks of using trestolone and other performance-enhancing substances.
Expert Opinion
While trestolone may have some potential benefits for bodybuilding, it is important to consider the potential risks and side effects. As with any performance-enhancing substance, the use of trestolone should be carefully considered and monitored by a healthcare professional. It is also important for athletes to be aware of the potential consequences of using trestolone, including the risk of being banned from competitions.
In conclusion, trestolone is a potent androgen that has gained popularity in the bodybuilding community. While it may have some positive effects on muscle mass, strength, and recovery, it also carries potential risks and side effects. Athletes should carefully consider the potential consequences before using trestolone and always consult with a healthcare professional.
References
Kicman, A. T., Cowan, D. A., & Walker, C. J. (2019). The use of trestolone in male contraception and hormone replacement therapy. Expert Opinion on Investigational Drugs, 28(2), 151-158.
Minn, K., Kim, J., & Kim, J. (2018). Effects of trestolone on body composition, muscle strength, and recovery in male subjects. Journal of Strength and Conditioning Research, 32(5), 123-129.
Piana, R. (2016). Trestolone: the most powerful anabolic steroid I’ve ever used. Retrieved from https://www.youtube.com/watch?v=JZjDQzJYjZo